EXPLORING THE KETOGENIC DIET: IMPACTS, CONTROVERSIES IN METABOLIC SYNDROME MANAGEMENT AND BEYOND

Main Article Content

Nazarova Maftuna

Abstract

This review article provides a comprehensive examination of the ketogenic diet (KD), a high-fat, low-carbohydrate dietary regimen, and its potential role in managing metabolic syndrome (MetS). The KD’s effectiveness in significantly impacting weight loss, BMI, glucose levels, insulin levels, HOMA-IR, HbA1c, total cholesterol, triglycerides, AST, and ALT is discussed. The article also explores the controversies surrounding the KD, including potential side effects and its role in cancer treatment. Future research directions, such as the link between the KD and the gut microbiome and its use in treating cardiovascular diseases, are highlighted. The article concludes by emphasizing the need for personalization in the KD and the necessity for long-term clinical trials to determine if the short-term effects of the KD translate into beneficial long-term outcomes.

Article Details

How to Cite
Nazarova Maftuna. (2024). EXPLORING THE KETOGENIC DIET: IMPACTS, CONTROVERSIES IN METABOLIC SYNDROME MANAGEMENT AND BEYOND. Uz-Conferences, 654–663. Retrieved from https://uz-conference.com/index.php/p/article/view/596
Section
Articles

References

Cervenka, M. C., Wood, S., Bagary, M., Balabanov, A., Bercovici, E., Brown, M. G., Devinsky, O., Di Lorenzo, C., Doherty, C. P., Felton, E., Healy, L. A., Klein, P., Kverneland, M., Lambrechts, D., Langer, J., Nathan, J., Munn, J., Nguyen, P., Phillips, M., … Zupec-Kania, B. (2021). International Recommendations for the Management of Adults Treated With Ketogenic Diet Therapies. Neurology: Clinical Practice, 11(5), 385–397. https://doi.org/10.1212/CPJ.0000000000001007

Charlot, A., & Zoll, J. (2022). Beneficial Effects of the Ketogenic Diet in Metabolic Syndrome: A Systematic Review. Diabetology 2022, Vol. 3, Pages 292-309, 3(2), 292–309. https://doi.org/10.3390/DIABETOLOGY3020020

Chen, J. P., Chen, G. C., Wang, X. P., Qin, L., & Bai, Y. (2017). Dietary Fiber and Metabolic Syndrome: A Meta-Analysis and Review of Related Mechanisms. Nutrients 2018, Vol. 10, Page 24, 10(1), 24. https://doi.org/10.3390/NU10010024

Dayi, T., & Ozgoren, M. (2022). Effects of the Mediterranean diet on the components of metabolic syndrome. Journal of Preventive Medicine and Hygiene, 63(2 Suppl 3), E56–E64. https://doi.org/10.15167/2421-4248/JPMH2022.63.2S3.2747

Dowis, K., & Banga, S. (2021). The potential health benefits of the ketogenic diet: A narrative review. In Nutrients (Vol. 13, Issue 5). MDPI AG. https://doi.org/10.3390/nu13051654

Gershuni, V. M., Yan, S. L., & Medici, V. (2018a). Nutritional Ketosis for Weight Management and Reversal of Metabolic Syndrome. Current Nutrition Reports, 7(3), 97–106. https://doi.org/10.1007/S13668-018-0235-0/FIGURES/1

Gershuni, V. M., Yan, S. L., & Medici, V. (2018b). Nutritional Ketosis for Weight Management and Reversal of Metabolic Syndrome. Current Nutrition Reports, 7(3), 97–106. https://doi.org/10.1007/S13668-018-0235-0/FIGURES/1

Gough, S. M., Casella, A., Ortega, K. J., & Hackam, A. S. (2021). Neuroprotection by the Ketogenic Diet: Evidence and Controversies. In Frontiers in Nutrition (Vol. 8). Frontiers Media S.A. https://doi.org/10.3389/fnut.2021.782657

He, M., & Shi, B. (2017a). Gut microbiota as a potential target of metabolic syndrome: the role of probiotics and prebiotics. Cell & Bioscience 2017 7:1, 7(1), 1–14. https://doi.org/10.1186/S13578-017-0183-1

He, M., & Shi, B. (2017b). Gut microbiota as a potential target of metabolic syndrome: the role of probiotics and prebiotics. Cell & Bioscience 2017 7:1, 7(1), 1–14. https://doi.org/10.1186/S13578-017-0183-1

Kaushik, A. S., Strath, L. J., & Sorge, R. E. (2020). Dietary Interventions for Treatment of Chronic Pain: Oxidative Stress and Inflammation. Pain and Therapy, 9(2), 487–498. https://doi.org/10.1007/S40122-020-00200-5/TABLES/2

Patikorn, C., Saidoung, P., Pham, T., Phisalprapa, P., Lee, Y. Y., Varady, K. A., Veettil, S. K., & Chaiyakunapruk, N. (2023). Effects of ketogenic diet on health outcomes: an umbrella review of meta-analyses of randomized clinical trials. BMC Medicine, 21(1). https://doi.org/10.1186/s12916-023-02874-y

Shang, Q., Gao, Y., Tu, H., & Chen, T. (2022). Editorial: The role of dietary interventions in the regulation of host-microbe interactions: Volume II. Frontiers in Cellular and Infection Microbiology, 12, 1078271. https://doi.org/10.3389/FCIMB.2022.1078271/BIBTEX

Sukkar, S. G., & Muscaritoli, M. (2021). A Clinical Perspective of Low Carbohydrate Ketogenic Diets: A Narrative Review. Frontiers in Nutrition, 8, 642628. https://doi.org/10.3389/FNUT.2021.642628/BIBTEX

Zhang, W., Guo, X., Chen, L., Chen, T., Yu, J., Wu, C., & Zheng, J. (2021). Ketogenic Diets and Cardio-Metabolic Diseases. In Frontiers in Endocrinology (Vol. 12). Frontiers Media S.A. https://doi.org/10.3389/fendo.2021.753039